The Paill Spectrum model would predict that any patient with Celiac disease is likely to have a serious problem with Paill Spectrum infection.

 High levels of immune activation will occur in celiac patients. This results in high levels of pro-inflammatory mediators (Cytokines and interferon) in patients. Every one knows that when these natural chemicals in the body are elevated as for example when the body is fighting the flu, patients feel terrible. (Typical flu symptoms are aches, pains, malaise, fever, and headaches. These symptoms are more often due to the body’s natural defence chemicals ¨the cytokines and interferon than to the actual germs themselves. In fact patients given injection of interferon, develop typical flu like symptoms often. 

 Even though the immune system is activated it is not working effectively in celiac patients with underlying immune problems related to Gluten antigen processing (the allergy component of Celiac) as well as the nutritional complications (nutrient) deficiencies often occurring as well.

 In short, these patients find they have no energy, in modern terms called “Chronic Fatigue”. In traditional terms they are short of “qui” or energy. The two theories give very different explanations, but here is a kernel of truth behind the traditional Chinese medicine theory