Paill Spectrum predicts a role for this disease in the development of

Lipid changes (a complex list of changes depending on the stage of the infection, definitely affected by nutritional risk factors for Paill Spectrum),

Obesity, Hypoglycemia, Insulin resistance, Diabetes: all likely to be affected by nutritional changes as predicted by both the traditional Chinese medicine model as well as the Paill Spectrum disease model.

 Vitamin B deficiencies especially vitamin B12 or folic acid, or iron deficiencies, excessive cholesterol, excessive triglycerides, blood disorders and diabetes should be considered to be spleen disorders and can be addressed as macrobiotic issues as well. I.e. Feed the organ with the foods that it can break down and digest easily. A cholesterol problem should be addressed not only by cutting out fat, but by cutting out wheat and dairy as well. (As well as the other foods listed). This comment will be contentious, but the problem is more of digestion, than of fats.