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Paill Spectrum is the radical new model explaining the genesis of a number of medical conditions with no known cause.



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Dr Xxxxx has presented information about the Paill Spectrum syndrome and related conditions at conferences in Australia, New Zealand, and Florida. Information about psychosis has been published in the Internet Journal Online. Dr Xxxxx has been active in the media during his career with minor publications in Time Magazine, Brisbane TV media on Schistosomiasis.

References to Presentations

I have already presented the clinical syndrome has been presented to

  • Several hundred doctors at the 49th Annual Scientific Convention of the RACGP in Darwin in 29th September-2nd October, 2005
  • About a dozen of my close medical colleagues in mid-late 2005

  • Doctors in the USA at the Fifth Annual Forum for Improving Children’s Health Care, NICHQ Forum, Royal Pacific Resort, Orlando, Florida, March 16-18, 2006
  • RNZCGP "Practical Solutions", Auckland, New Zealand
    10th- 13th August 2006.
  • 16th Annual Mental Health Conference, "Reach Out & Connect"
    Townsville, North Qld.
  • 10th International Congress On Obesity, Sydney, NSW
    3rd- 8th September, 2006

  • 17th international Association for Child & Adolescent Psychiatry & Allied Health Professionals, Melbourne Victoria
    10th - 14th September, 2006
  • 49th RACGP Annual Scientific Conference, Brisbane, Qld
    5th - 8th October, 2006
  • 3rd International Conference of Healthy Aging & Longevity, Melbourne, Victoria
    13th- 5th October, 2006


It has taken approximately a year of lead-time to organise this level of exposure
for my medical syndrome model
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References to Presentations : 1

Conference; RACGP 48th Annual Scientific Convention: Darwin

Title: New Cause for Chronic Fatigue

Purpose:

GPs are the most accessible and available medical practitioners in the health care system to identify the variable presentations of patients with chronic fatigue in a newly identified symptom cluster

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Objectives:

To allow GPs to identify and treat patients with chronic tiredness and other related symptoms.

 

Methods:

Long-term work with general practice patients has allowed identification of a characteristic symptom cluster.  Longitudinal case control observations of these identified patients have further identified consistent patterns of pathology testing and responses to treatment.

Results and Findings:

This symptom cluster consists of:

Chronic fatigue, Sweaty hands, Chest and Elbow pain, and Loss of Balance

These are the most basic and important symptoms of the symptom cluster.  They form a distinct reliably recognisable case description.

The symptom intensity is variable.  Many patients do not realise they have tender areas until the doctor performs the examination.  Static and dynamic balance testing is required to reveal the extent of the loss of balance.  Illness appears over a very long time and very gradually.  People often are embarrassed to mention the symptoms because they feel they are not important.  Most people know they have something wrong with themselves, but have been often unable to find an effective treatment

The symptom pattern and blood test findings form a distinct recognisable clinical entity.  The symptom cluster is associated with a characteristic profile of pathology test results.  The blood tests measure: disease presence, diseases flares, disease remissions with treatment, relapses. Back to References top

 

There are two main types of blood tests.

  • Nutritional tests appear to relate to how well the immune system functions.
  • Inflammatory markers measure the body’s immune response in the condition.  Problems are often caused by nutritional and medical problems that affect the immune system, such as diabetes.

 

The challenge in general medical practice is to diagnose the symptoms cluster early and to prevent progressive worsening of the symptoms.

 

1.      I have called the symptom cluster and the other presentations of the illness: Paill Spectrum.  The condition causes a variety of illnesses, including chronic fatigue.  Abnormal behaviours and irritability as may be seen in people with Road Rage or trolley rage are common. Back to References top

2.      What does this illness look like?

.







References to Publications : 2

As Published in: Internet Journal Online

Author: Dr Andrew Xxxxx
31 Samuel St
Camp Hill
Queensland       Australia           4152.         
Ph.       61 7 3398 6233                          Fax.      61 7 3398 6433     

Contact for general enquiries, contact us at:

Antibiotic Treatable Psychosis: Paill Spectrum Syndrome
Contemporary Australian General Practice Research: Case Reports

A number of patients with characteristic specific symptoms and signs have been identified in a general practice clinic.  These cases are all associated with a characteristic pattern of medical symptoms and signs, as well as a characteristic pattern of blood tests findings.  The “symptom and blood test” patterns were identified through longitudinal case control observations of patients in general practice. 

 

The basic symptoms form a distinct reliably recognisable “syndrome” description.  Illness appears over a very long time and very gradually.  The symptom cluster is associated with a characteristic profile of pathology blood test results. This syndrome description has been named Paill Spectrum.
(More details on the Quizdoc website www.quizdoc.com)
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Cases A, B, C form a subset of this case description, in that they all demonstrate thought disorder.

 

Case A showed a disorganized type of thought disorder, with inability to answer questions logically.  This changed rapidly on treatment, with return of normal thought processes.

Case B was fixated on a single illogical thought that was stated as “no bones.”  All questions to the patient were answered with disorganised versions of this statement.  The symptoms of thought disorder improved rapidly on treatment.

Cases A & B were acute illnesses with symptoms less than six months old. 

Case C was able to speak coherently but was experiencing auditory hallucinations.  The voices had prompted him to jump out of a moving car and to stab himself with a knife on several occasions.  The auditory hallucinations disappeared on treatment.  The deliberate self-harm and other risky behaviours eased considerably on treatment.

 

The basic symptom cluster of the Paill Spectrum Syndrome found "variably" in all these patients includes:

 

  • Chronic Fatigue or Tiredness,
  • Sweaty hands,
  • Abdominal Tenderness in para-aortic regions
  • Loss of Balance.
  • A characteristic learning disability (dyslexia like), may be present.
  • The behavioural component of the symptom cluster includes: irritability and mood swings, aggression and proneness to violence, loss of short-term memory or forgetfulness, impulsiveness, and small episodes of panics or jitters. Back to References top

 

 

There are blood tests measuring nutrition and inflammation status in Paill Spectrum Syndrome:

  • Identified nutritional abnormalities include: borderline or deficient B12/ folate status, antigliaden antibodies greater than 25% reference range as calibrated for endoscopically proven Celiac disease, and low normal zinc levels.
  • Identified inflammatory abnormalities include a total quantified antibody level (GAM) greater than 11, occasional appearance of low C3 and minor elevations of ANF.  FBC is characteristically normal.

  

While the EPP Gamma has been used as an assessment for initial cases, it has been replaced by a quantitation of IgG+IgA+IgM.  When the calculation IgG+IgA+IgM-1.0 g/l is used, the resulting number is called the "GAM1". 

This figure allows comparison of quantitated total immunoglobulin levels (IgG+IgA+IgM) with the EPP Gamma (semi-quantitative) assay, by allowing for an characteristically average migration of 1.0 g/l of IgA immunoglobulin in the Beta band of the EPP.  The actual amount of IgA migrating in the Beta band of the EPP is quite variable, so direct measurement of immunoglobulin is preferable in assessment.

 


Case A:

  • ·         EPP Gamma Quantitated at 15, equivalent to an approximate GAM 16 g/l on average, (allowing for the usual average of 1.0 g/l immunoglobulin IgA type, migrating in the Beta band)
  • ·         Zinc 11.0 microM (RR 12.0-29.0)
  • ·         Antigliaden IgG 0.45 (RR <1.00)
  • ·         Antigliaden IgA 0.27 (RR <1.00)

Case A: Comment

  • EPP is high
  • Serum Zinc level is low
  • Antigliaden antibodies at greater than 20% reference suggest that a trial of dietary therapy may have a symptomatic benefit.

 

Case B:

  • ·         GAM Total 15.17 (GAM1= 14.17)
  • ·         Serum Zinc 13.1 (RR 12.0-28.0)
  • ·         Antigliaden IgG 0.79 (RR<1.00)
  • ·         Antigliaden IgA 0.28 (RR <1.00)

Case B: Comment

  • EPP is high
  • Serum Zinc level is low-normal
  • Antigliaden antibodies at greater than 20% reference suggest that a trial of dietary therapy may have a symptomatic benefit. Back to References top

 

Case C:

  • ·         GAM Total 11.58 (GAM1=10.58)  
  • ·         Zinc 12 microM (RR 12-28)
  • ·         Antigliaden IgA: 0.06 (negative, RR <1.00)
  • ·         Antigliaden IgG: 0.23 (negative, RR <1.00)
  • ·         Deficient RBC Folate: 197 nM, 25% below quoted reference range.

 Case C: Comment

  • EPP is above diagnostic threshold, though lower than the other results of Case A and Case B.
  • Serum Zinc level is low-normal
  • Antigliaden antibodies at greater than 20% reference suggest that a trial of dietary therapy may have a symptomatic benefit.  This result is "borderline" for probability of success of trial of “gluten avoiding” dietary therapy.

 



Treatments instituted for the Paill Spectrum Syndrome were:

  • ·         Daily multivitamin supplement
  • ·         44 mg elemental zinc daily
  • ·         Antibiotics: Minocycline 100 mg daily for a minimum of three months

.

Results: in all cases:

Improvement or Resolution of the thought disorder becomes obvious from within two weeks.  Substantial obvious mood improvement in terms of reduced irritability and reduced anger were also noticed within two weeks.  Changes were obvious to the patient, their relatives and their carers. Treatment achieves a plateau of mood improvement and thought disorder improvement, within about three months. Back to References top

 

Dr. Andrew Xxxxx (Contact via quizdoc.com website : Clinical Contact pages)

Contact for general enquiries, contact us at:










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References to Presentations : 3

RNZCGP Approx Aug 2006, RACGP approx. Sept. 2006 Conference Presentations

Medical Treatment of Dyslexia Like Syndromes In Early Childhood

Author: Dr Andrew Xxxxx
31 Samuel St, Camp Hill, 4152.     

Contact for general enquiries, contact us at:






Contemporary Australian Research Paper

Purpose:

GPs are the most accessible and available medical practitioners in the health care system to identify the variable presentations of patients with dyslexia in a newly identified symptom cluster

 

Objectives:

Simple assessment techniques rapidly reveal children who have characteristic, significant, and medically treatable learning disabilities.  Nutritional factors important to treatment can often be addressed by the provision of basic information to both parents and children.  Medical therapy needs to be followed by intensive education of affected children.

 

Methods:

Long term work with general practice patients has allowed identification of a characteristic symptom cluster.  Longitudinal case control observations of these identified patients has further identified consistent patterns in responses to treatment. Back to References top

 

Results and Findings:

Simple recall testing of numerical sequences reveals a characteristic pattern of memory errors.  These errors are easily identified and are unique to the dyslexia-like symptom pattern identified.  The symptom intensity is variable.  Many children do not complain of symptoms and cases must be suspected and identified by doctors, teachers, and educators.

 

Failure to identify affected children results in a very poor outlook for the affected children from their treatable learning disability.  Social complications for the affected children also occur.  These include: sleepiness, tiredness, poor memory, lower physical activity, mood changes, and irritability.  Many of the more severely affected children will often have low weight in spite of their relative physical inactivity, due to basic underlying nutritional problems.

The symptom cluster is associated with a characteristic profile of pathology blood test results.

 

The challenge in early childhood is to identify the symptoms early and to prevent progressive worsening of the learning disability. Back to References top

 

I have called the symptom cluster and the other presentations of the illness: Paill Spectrum.  The condition causes a variety of illnesses, including chronic tiredness.  Abnormal behaviours and irritability as may often also be seen.






References to Presentations : 4

17th International Association for Child Adolescent Psychiatry & Allied Professions 2006

 Medically Treatable Adolescent Irritability & Behavioural Changes

Author: Dr Andrew Xxxxx
 31 Samuel St,   Camp Hill, 4152.
 Ph:  07 3398 6233                                       Fax.: 07  33986433

Contact for general enquiries, contact us at:








Submission: Contemporary Australian Research Paper ( General Practice)

 

Purpose:

Behavioural changes in adolescents presenting in a suburban general practice can be influenced by medical and nutritional therapies.

 

Objectives of Presentation:

To allow health and educational workers to identify a symptom cluster characteristic of potentially treatable adolescents with behavioural changes. Back to References top

 

Methods:

Long term work with general practice patients has allowed identification of a characteristic symptom cluster. Longitudinal case control observations of these identified patients has further identified consistent patterns of pathology testing and responses to treatment.

 

Results and Findings:

This symptom cluster in adolescents consists of :

Fatigue, Sweaty hands, Abdominal Pain, Loss of Balance. A characteristic learning disability may also be present. These basic symptoms  form a distinct reliably recognisable case description.

Illness appears over a very long time and very gradually, though usually is exacerbated substantially by the appearance of puberty. Back to References top

 

The symptom cluster is associated with a characteristic profile of pathology blood test results. The blood tests measure nutrition and inflammation.

The challenge is to diagnose the symptom cluster early and to prevent progressive worsening of the symptoms. Failure to identify affected children results in a very poor outlook for the affected children. Learning disabilities and social complications are common long term difficulties experienced by these adolescents.

 

I have called the symptom cluster and the other presentations of the illness : Paill Spectrum. The condition causes a variety of illnesses, including chronic fatigue. Abnormal behaviours and irritability are common. Back to References top









References to Presentations : 5

Mental Health Services Conference

Contemporary Australian General Practice Research
Antibiotic Treatable Psychosis

Keywords: Paill Spectrum, Sweaty Hands, Dizziness

Purpose: To assist doctors to identify cases of potentially treatable psychosis

 

Methods:

Long-term work with general practice patients has allowed identification of a characteristic symptom cluster.  Longitudinal case control observations of these identified patients has further identified consistent patterns in responses to treatment.  A case cluster of patients with thought disorder identified over two years, demonstrate response to antibiotic therapies.

Thought disorder is a rare accompaniment of the symptom/ blood tests cluster.

 

 

Objectives:

Develop recognition of the Paill Spectrum symptom cluster amongst doctors, as a potentially treatable form of psychosis. Back to References top

Relevant to mental health issues as a form of potentially antibiotic treatable psychosis.

  

Results and Findings:

These symptom and blood tests patterns were identified through longitudinal case control studies of patients in general practice. 

The symptom cluster found variably in these patients includes:

Chronic Fatigue or tiredness, Sweaty hands, Abdominal Tenderness in para-aortic regions and Loss of Balance, often called dizziness.  A characteristic learning disability (dyslexia like), may also be present.  The symptom cluster is associated with a characteristic profile of pathology blood test results.  The blood tests measure nutrition and inflammation.

These cases are all associated with a characteristic pattern of medical symptoms and signs as well as a characteristic pattern of blood tests.

Other symptoms and signs of illness may be found in other patients with this condition.  The symptom intensity is variable. Back to References top

Failure to identify affected patients results in a very poor outlook for the affected children from their treatable medical condition.  Social complications for the affected patients also occur.






References to Presentations : 6

10TH International Congress on Obesity approx. Sept. 2006

Heading: Infective Cause for Obesity: Clinical Syndrome in General Practice

Topic Heading: Insulin Resistance

Methods:

Observation of general practice patients has allowed identification of a characteristic symptom cluster.  A long-term complication of this syndrome cluster is the “sudden” appearance of weight gain over several years.  The weight effects of the syndrome appear to be mediated both via behavioural and metabolic processes.

 

Objectives:

Develop recognition of the Paill Spectrum symptom cluster amongst doctors, as a cause of weight gain in a number of patients.

 

Results and Findings:

These cases are all associated with a characteristic pattern of medical symptoms and signs as well as a characteristic pattern of blood tests. Back to References top

The symptom intensity is variable.  These symptom and blood tests patterns were identified through longitudinal case control studies of patients in general practice. 

The symptom cluster found variably in these patients includes:

Chronic Fatigue or tiredness, Sweaty hands, Abdominal Tenderness in para-aortic regions and Loss of Balance.  Other symptoms and signs of illness may be found in other patients with this condition. 

The symptom cluster is associated with a characteristic profile of pathology blood test results.  The blood tests measure nutrition and inflammation.

Social complications for the affected patients also occur, in addition to the problems directly related to the weight gain Back to References top.



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CD Book Information
The CD Books are not currently available. (Planned release date is early 2008). 

     

More information is available on Paill Spectrum in Dr. Andrew Xxxxx’s two CD Books:

The CD Book with much more specific medical detail is called CTC-DTM . This CD gives full detail on identification of symptoms, signs of illness as well as full detail on treatment.

CTC-PSS is a discussion on the development of the PaillSpectrum model and the treatment of Chronic Fatigue. A number of cases are included to teach identification of key symptoms & signs on medical history & examination. :-0 Back to References top

Accessing Information
Downloadable Information files (zip = pdf +mp3), are available directly through the web site. 
(File on the
Download Page: approximately 12MB download). :-? :-O

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The Paill Spectrum Disease Model has been developed by Dr. Andrew Xxxxx. It will be some time before the knowledge of the syndrome becomes independently tested and accepted. Disclaimer



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